LRP-6 Protein, Human, Recombinant (mFc)

Catalog No. TMPK-00744

Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin. LRP-6 Protein, Human, Recombinant (mFc) is expressed in HEK293 Cells. The accession number is O75581-1.

LRP-6 Protein, Human, Recombinant (mFc)

Catalog No. TMPK-00744

Pack Size	Price	Availability
100 μg	$371	7-10 days
500 μg	$1,490	7-10 days
1 mg	$2,480	7-10 days

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Product Information

Biological Activity	Immobilized Human DKK1, His Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 0.58 μg/mL determined by ELISA. Immobilized Human SOST, His Tag at 2 μg/mL (100 μL/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 13.1 ng/mL determined by ELISA. Immobilized Human LRP-6, mFc Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Human R spondin 1, His Tag with the EC50 of 4.4 μg/mL determined by ELISA.
Description	Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin. LRP-6 Protein, Human, Recombinant (mFc) is expressed in HEK293 Cells. The accession number is O75581-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-mFc (IgG2a)
Accession Number	O75581-1
Synonyms	LRP-6,LRP6,FLJ90421,FLJ90062,DCAD2
Construction	Ala20-Pro630
Protein Purity	> 90% as determined by Tris-Bis PAGE
Molecular Weight	95.32 kDa (predicted); 97-110 kDa (Bis-Tris PAGE, due to glycosylation)
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin.