Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated

Catalog No. TMPY-05813

Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297.

Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated

Catalog No. TMPY-05813

Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297.

Pack Size	Price	Availability	Quantity
20 μg	$306	7-10 days
100 μg	$726	7-10 days

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Product Information

Biological Activity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	Q02297
Synonyms	SMDF,NRG1-IT2,neuregulin 1,NDF,MSTP131,MST131,HRGA,HRG1,HRG,HGL,GGF2,GGF,ARIA
Construction	A DNA sequence encoding the N-terminal fragment (Ser2-Lys246) of human NRG1 isoform beta1 (Q02297-6) was expressed. The purified protein was biotinylated in vitro. Predicted N terminal: Ser2
Protein Purity	> 75 % as determined by SDS-PAGE.
Molecular Weight	26.8 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.