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TEM8/ANTXR1 Protein, Human, Recombinant (His)

Catalog No. TMPY-07113

TEM8/ANTXR1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q9H6X2-1.

TEM8/ANTXR1 Protein, Human, Recombinant (His)

TEM8/ANTXR1 Protein, Human, Recombinant (His)

Catalog No. TMPY-07113
TEM8/ANTXR1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q9H6X2-1.
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Product Information

Biological Activity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
TEM8/ANTXR1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q9H6X2-1.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberQ9H6X2-1
Synonyms
TEM8,GAPO,FLJ21776,FLJ10601,ATR
Construction
A DNA sequence encoding the Human ANTXR1 (NP_115584.1) (Met1-Ser321) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity
≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
Molecular Weight33.85 kDa (predicted); 41.1 kDa (reducing contition, due to glycosylation)
Endotoxin< 1.0 EU per μg protein as determined by the LAL method.
FormulationLyophilized from sterile PBS, 10% Glycerol, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution
Please refer to the lot-specific COA.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases and belongs to the phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by phosphorylating a number of key proteins. ANTXR1 interacts with extracellular matrix proteins and with the actin cytoskeleton. It functions in cell attachment and migration. ANTXR1 also mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

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