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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 μg | $118 | In Stock | |
50 μg | $350 | 7-10 days | |
500 μg | $1,520 | 7-10 days | |
1 mg | $3,790 | 7-10 days |
Biological Information | Immobilized Mouse TGFBR2 -Fc at 10μg/ml (100 μl/well) can bind Mouse/Rat TGF-beta 2*.*: Biotinylated by NHS-biotin prior to testing. The ED50 of Mouse TGFBR2 -Fc is 0.136 ug/ml. (Regularly tested) ![]() |
Description | Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. |
Species | Mouse,Rat |
Expression System | HEK293 Cells |
Tag | Tag Free |
Accession Number | P27090 |
Synonyms | transforming growth factor β-2,BSC-1 cell growth inhibitor,G-TSF,TGF-β-2,TGF-beta2,MGC116892,Polyergin,Cetermin,TGF-β2,TGFB2,TGF-beta-2,transforming growth factor beta-2,Glioblastoma-derived T-cell suppressor factor |
Amino Acid | Ala303-Ser414 |
Construction | Ala303-Ser414 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) ![]() |
Molecular Weight | 12 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 4 mM HCl. |
Reconstitution | Reconstitute the lyophilized protein in 4mM HCl. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. |
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