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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 μg | $130 | 7-10 days | |
50 μg | $394 | 7-10 days | |
500 μg | $1,980 | 7-10 days | |
1 mg | $2,970 | 7-10 days |
Biological Information | 1. Loaded Human TPBG Antibody (5G9) (Human IgG1) on Protein-A Biosensor, can bind Human TPBG (C-mFc) with an affinity constant of 8.75 nM as determined in BLI assay. (Regularly tested)
2. Immobilized Human TPBG (C-mFc) at 2μg/ml (100 μl/well) can bind Human TPBG Antibody (5G9) (Human IgG1) . The ED50 of Human TPBG Antibody (5G9) (Human IgG1) is 1.57 ng/ml. (Regularly tested) |
Description | 5T4/TPBG Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 80-110 KDa and the accession number is Q13641. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-mFc |
Accession Number | Q13641 |
Synonyms | TPBG,5T4 Protein,M6P1 Protein,5T4AG Protein,WAIF1 Protein |
Amino Acid | Ser32-Ser355 |
Construction | Ser32-Ser355 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 80-110 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. |
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