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TROP-2 Protein, Human, Recombinant (His & Avi), Biotinylated

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TROP-2 Protein, Human, Recombinant (His & Avi), Biotinylated

Catalog No. TMPY-06378

TROP-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 31.14 kDa and the accession number is NP_002344.2.

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Pack Size	Price	Availability	Quantity
20 μg	$600	7-10 days
100 μg	$1,390	7-10 days

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Biological Description

Biological Information	Loaded Anti-Human TROP2 antibody, human IgG1 on ProA Biosensor, can bind Recombinant Human TROP2 Protein, His Tag with an affinity constant of 0.373nM as determined in BLI assay (Routinely tested).
Description	TROP-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 31.14 kDa and the accession number is NP_002344.2.
Species	Human
Expression System	HEK293 Cells
Tag	C-His-Avi
Accession Number	NP_002344.2
Synonyms	EGP-1,GA733-1,GP50,TACD2,TROP2,EGP1,TROP-2,M1S1,GA7331,tumor-associated calcium signal transducer 2
Construction	The Human TACSTD2 (NP_002344.2) (Met1-Thr274) was expressed with a C-terminal polyhistidine tag followed by an AVI tag. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Protein Purity	> 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-HPLC.
Molecular Weight	31.14 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 25 mM Sodium Citrate, 200 mM NaCl, 0.02%Tween 80, 10% Trehalose , pH 6. 0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.