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TROP-2 Protein, Human, Recombinant (Avi & His), Biotinylated

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TROP-2 Protein, Human, Recombinant (Avi & His), Biotinylated

Catalog No. TMPJ-00204

Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions. TROP-2 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 40-60 KDa and the accession number is P09758.

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Pack Size	Price	Availability	Quantity
20 μg	$355	7-10 days
100 μg	$963	7-10 days

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Biological Description

Biological Information	1. Loaded Anti-Human TROP-2 mAb-Fc on Protein A Biosensor, can bind Biotinylated Human TROP-2-Avi-His with an affinity constant of 0.49 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Biotinylated Human TROP-2-Avi-His at 1μg/ml (100 μl/well) can bind Anti-Human TROP-2 mAb. The ED50 of Anti-Human TROP-2 mAb is 4.19 ng/ml. (Regularly tested)
Description	Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions. TROP-2 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 40-60 KDa and the accession number is P09758.
Species	Human
Expression System	HEK293 Cells
Tag	C-Avi-6xHis
Accession Number	P09758
Synonyms	TACSTD2,Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,TROP2,Tumor-associated calcium signal transducer 2
Amino Acid	His27-Thr274
Construction	His27-Thr274
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	40-60 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.