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USP46 Protein, Human, Mouse, Recombinant

Catalog No. TMPY-03011

USP46 Protein, Human, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.4 kDa and the accession number is P62069.

USP46 Protein, Human, Mouse, Recombinant

USP46 Protein, Human, Mouse, Recombinant

Catalog No. TMPY-03011
USP46 Protein, Human, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.4 kDa and the accession number is P62069.
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100 μg665 €7-10 days
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Product Information

Biological Activity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
USP46 Protein, Human, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.4 kDa and the accession number is P62069.
Species
Human,Mouse
Expression System
Baculovirus Insect Cells
TagTag Free
Accession NumberP62069
Synonyms
ubiquitin specific peptidase 46
Construction
A DNA sequence encoding the human / mouse USP46 [(Identical to the mouse USP46 (NP_808229.1)] (Met1-Glu366) was expressed. Human and Mouse USP46 sequences are identical. Predicted N terminal: Met
Protein Purity
> 95 % as determined by SDS-PAGE
Molecular Weight42.4 kDa (predicted); 43 kDa (reducing condition, due to glycosylation)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, pH 7.4, 10% gly. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
USP46 belongs to the peptidase C19 family, USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolyases, ubiquitin isopeptidases, or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. Besides ubiquitin recycling, they are also involved in processing of ubiquitin precursors, in proofreading of protein ubiquitination and in disassembly of inhibitory ubiquitin chains. USP46 is a deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.

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