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(+)-SHIN1

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Catalog No. T12898Cas No. 2443966-90-1
Alias (+)-RZ-2994

(+)-SHIN1 ((+)-RZ-2994) is the active (+) enantiomer of SHIN1, which inhibits human serine hydroxymethyltransferase 1 and 2 (SHMT1/2).

(+)-SHIN1

(+)-SHIN1

😃Good
Catalog No. T12898Alias (+)-RZ-2994Cas No. 2443966-90-1
(+)-SHIN1 ((+)-RZ-2994) is the active (+) enantiomer of SHIN1, which inhibits human serine hydroxymethyltransferase 1 and 2 (SHMT1/2).
Pack SizePriceAvailabilityQuantity
25 mg$1,4706-8 weeks
50 mg$1,9206-8 weeks
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Product Introduction

Bioactivity
Description
(+)-SHIN1 ((+)-RZ-2994) is the active (+) enantiomer of SHIN1, which inhibits human serine hydroxymethyltransferase 1 and 2 (SHMT1/2).
In vitro
(+)-SHIN1 ((+)-RZ-2994) exhibits potent inhibition of cytosolic SHMT1, with IC50 values of less than 50 nM in SHMT2 deletion cells and 870 nM in HCT-116 cells, effectively blocking cell growth [1].
Alias(+)-RZ-2994
Chemical Properties
Molecular Weight400.47
FormulaC24H24N4O2
Cas No.2443966-90-1
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (249.71 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4971 mL12.4853 mL24.9707 mL124.8533 mL
5 mM0.4994 mL2.4971 mL4.9941 mL24.9707 mL
10 mM0.2497 mL1.2485 mL2.4971 mL12.4853 mL
20 mM0.1249 mL0.6243 mL1.2485 mL6.2427 mL
50 mM0.0499 mL0.2497 mL0.4994 mL2.4971 mL
100 mM0.0250 mL0.1249 mL0.2497 mL1.2485 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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