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(+)-SHIN1 ((+)-RZ-2994) is the active (+) enantiomer of SHIN1, which inhibits human serine hydroxymethyltransferase 1 and 2 (SHMT1/2).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,470 | 6-8 weeks | |
50 mg | $1,920 | 6-8 weeks |
Description | (+)-SHIN1 ((+)-RZ-2994) is the active (+) enantiomer of SHIN1, which inhibits human serine hydroxymethyltransferase 1 and 2 (SHMT1/2). |
In vitro | (+)-SHIN1 ((+)-RZ-2994) exhibits potent inhibition of cytosolic SHMT1, with IC50 values of less than 50 nM in SHMT2 deletion cells and 870 nM in HCT-116 cells, effectively blocking cell growth [1]. |
Alias | (+)-RZ-2994 |
Molecular Weight | 400.47 |
Formula | C24H24N4O2 |
Cas No. | 2443966-90-1 |
Relative Density. | 1.32 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (249.71 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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