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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $98 | 35 days | |
50 μg | $195 | 35 days | |
100 μg | $363 | 35 days | |
500 μg | $1,600 | 35 days |
Description | (±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-2 microglia stimulated by LPS and decreases LPS-induced cytotoxicity when used at concentrations ranging from 5 to 10 μM. It also decreases nitrite production when used at a concentration of 7.5 μM, an effect that can be partially reversed by the CB2 receptor antagonist AM630 and the PPARγ antagonist GW 9662 . (±)19(20)-EDP ethanolamide induces vasodilation of isolated preconstricted bovine coronary arteries (ED50 = 1.9 μM) and reduces tube formation by human microvascular endothelial cells (HMVECs) in a Matrigel assay. |
Molecular Weight | 387.564 |
Formula | C24H37NO3 |
Cas No. | 2123485-34-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMF: 50 mg/mL Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL DMSO: 50 mg/mL Ethanol: 50 mg/mL |
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