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TOPBioactivityChemical infoStorage&SolubilityCalculator

(±)8(9)-DiHET

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Catalog No. T37227Cas No. 192461-96-4

Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.

(±)8(9)-DiHET

(±)8(9)-DiHET

😃Good
Catalog No. T37227Cas No. 192461-96-4
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
Pack SizePriceAvailabilityQuantity
25 μgInquiry35 days
50 μgInquiry35 days
100 μgInquiry35 days
250 μgInquiry35 days
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Product Introduction

Bioactivity
Description
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
Chemical Properties
Molecular Weight338.488
FormulaC20H34O4
Cas No.192461-96-4
Relative Density.1.025 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
PBS (pH 7.2): 1 mg/mL (2.95 mM), Sonication is recommended.
Ethanol: 50 mg/mL (147.72 mM), Sonication is recommended.
DMSO: 50 mg/mL (147.72 mM), Sonication is recommended.
DMF: 50 mg/mL (147.72 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM2.9543 mL14.7716 mL29.5431 mL147.7157 mL
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM0.5909 mL2.9543 mL5.9086 mL29.5431 mL
10 mM0.2954 mL1.4772 mL2.9543 mL14.7716 mL
20 mM0.1477 mL0.7386 mL1.4772 mL7.3858 mL
50 mM0.0591 mL0.2954 mL0.5909 mL2.9543 mL
100 mM0.0295 mL0.1477 mL0.2954 mL1.4772 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(±)8(9)DiHET(±)8(9) DiHET8(9)-DiHET
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