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(1α,1'S,4β)-Lanabecestat

Name: (1α,1'S,4β)-Lanabecestat
Brand: TargetMol
SKU: T10014
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T10014Cas No. 1384082-96-5

Alias (1α,1'S,4β)-AZD3293

(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzyme 1 (BACE1) inhibitor with IC50 values of 2.2 nM in the TR-FRET assay and 0.28 nM in the sAPPp release assay.

(1α,1'S,4β)-Lanabecestat

😃Good

Catalog No. T10014Alias (1α,1'S,4β)-AZD3293Cas No. 1384082-96-5

(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzyme 1 (BACE1) inhibitor with IC50 values of 2.2 nM in the TR-FRET assay and 0.28 nM in the sAPPp release assay.

Pack Size	Price	Availability
2 mg	$108	5 days
50 mg	$728	8-10 weeks
100 mg	$1,240	8-10 weeks

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Product Introduction

Bioactivity

Description	(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzyme 1 (BACE1) inhibitor with IC50 values of 2.2 nM in the TR-FRET assay and 0.28 nM in the sAPPp release assay.
Alias	(1α,1'S,4β)-AZD3293

Chemical Properties

Molecular Weight	412.53
Formula	C₂₆H₂₈N₄O
Cas No.	1384082-96-5
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (606.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4241 mL	12.1203 mL	24.2407 mL	121.2033 mL
5 mM	0.4848 mL	2.4241 mL	4.8481 mL	24.2407 mL
10 mM	0.2424 mL	1.2120 mL	2.4241 mL	12.1203 mL
20 mM	0.1212 mL	0.6060 mL	1.2120 mL	6.0602 mL
50 mM	0.0485 mL	0.2424 mL	0.4848 mL	2.4241 mL
100 mM	0.0242 mL	0.1212 mL	0.2424 mL	1.2120 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(1a,1'S,4b)-AZD 3293(1α,1'S,4β)-AZD 3293(1α,1'S,4β) Lanabecestat(1alpha,1'S,4beta)-Lanabecestat(1α,1'S,4β)-AZD-3293(1a,1'S,4b)-AZD-3293(1a,1'S,4b)-AZD3293(1alpha,1'S,4beta)-AZD-3293(1a,1'S,4b)-Lanabecestat(1alpha,1'S,4beta)-AZD3293(1alpha,1'S,4beta)-AZD 3293(1α,1'S,4β)Lanabecestat(1α,1'S,4β)-Lanabecestat