Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | 4-5 weeks | $ 1,880.00 |
Description | (R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM). |
Targets&IC50 | H3 receptor:50.3 nM (kd) |
In vitro | (R)-(-)-α-Methylhistamine dihydrobromide is an H3-agonist that is > 10 times as potent as histamine (HA).(R)-(-)-α-Methylhistamine dihydrobromide has only weak affinities for H1 and H2 receptor with a pKi=4.8 and < 3.5, repectively. Its selectivity toward H3-receptors is > 1,000 times as high as that of HA. (R)-(-)-α-Methylhistamine dihydrobromide displays >200-fold selectivity over H4 receptors[1]. |
In vivo | (R)-alpha-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[2].Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide reverses propofol‐induced memory retention[4]. |
Molecular Weight | 287 |
Formula | C6H13Br2N3 |
CAS No. | 868698-49-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(R)-(-)-α-Methylhistamine dihydrobromide 868698-49-1 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor a-Methylhistamine Dihydrobromide alpha-Methylhistamine Dihydrobromide (R)()αMethylhistamine dihydrobromide a-Methylhistamine α-Methylhistamine Dihydrobromide α-Methylhistamine alpha-Methylhistamine (R) ( ) α Methylhistamine dihydrobromide inhibitor inhibit