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(E)-5-(2-Bromovinyl)uracil

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Catalog No. T35439Cas No. 69304-49-0

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), which can be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner, enhancing the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, thereby increasing survival time.

(E)-5-(2-Bromovinyl)uracil

(E)-5-(2-Bromovinyl)uracil

😃Good
Catalog No. T35439Cas No. 69304-49-0
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), which can be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner, enhancing the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, thereby increasing survival time.
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Product Introduction

Bioactivity
Description
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), which can be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner, enhancing the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, thereby increasing survival time.
Chemical Properties
Molecular Weight217.02
FormulaC6H5BrN2O2
Cas No.69304-49-0
Relative Density.1.881 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 60 mg/mL (276.47 mM), Sonication is recommended.
PBS (pH 7.2): 8 mg/mL (36.86 mM), Sonication is recommended.
DMSO: 53 mg/mL (244.22 mM), Sonication is recommended.
Ethanol: 0.8 mg/mL (3.69 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/PBS (pH 7.2)/DMSO/DMF
1mg5mg10mg50mg
1 mM4.6079 mL23.0394 mL46.0787 mL230.3935 mL
PBS (pH 7.2)/DMSO/DMF
1mg5mg10mg50mg
5 mM0.9216 mL4.6079 mL9.2157 mL46.0787 mL
10 mM0.4608 mL2.3039 mL4.6079 mL23.0394 mL
20 mM0.2304 mL1.1520 mL2.3039 mL11.5197 mL
DMSO/DMF
1mg5mg10mg50mg
50 mM0.0922 mL0.4608 mL0.9216 mL4.6079 mL
100 mM0.0461 mL0.2304 mL0.4608 mL2.3039 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

(E) 5 (2 Bromovinyl)uracil(E)5(2Bromovinyl)uracil5-(2-Bromovinyl)uracil
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