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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $98 | Backorder | |
10 mg | $173 | Backorder | |
50 mg | $760 | Backorder | |
100 mg | $1,327 | Backorder |
Description | Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers, and eggplants. Anatabine is an Aβ inhibitor. (R,S)-Anatabine (tart |
In vitro | In vitro: Anatabine dose-dependently lowered Aβ1-40 and Aβ1-42 levels and reduced sAPPβ production without any effects on sAPPα levels. Anatabine lowered Aβ production by mainly impacting the β-cleavage of APP. Anatabine lowered NFκB activation. Anatabine inhibited BACE-1 transcription and reduced BACE-1 protein levels in human neuronal-like SHSY-5Y cells. (R,S)-Anatabine also dose-dependently inhibits NF-κB activation [1]. |
In vivo | In vivo: In a transgenic mouse model with AD, treatment with anatabine for 4 days remarkably lowered brain soluble Aβ1-40 and Aβ1-42 levels [1]. |
Alias | (R,S)-Anatabine (tartrate) |
Molecular Weight | 310.3 |
Formula | C10H12O2·C4H6O6 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: 20mg/ml Ethanol: ≤1mg/mL |
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