(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker with a Ki of 0.56-2.1 μM for the NMDA receptor and IC50 values of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine shows antidepressant effects [1].

Lanicemine demonstrates enduring antidepressant effects while inducing minimal psychotomimetic side effects [1]. When administered intraperitoneally at doses of 3, 10, or 30 mg/kg, lanicemine not only activates brain circuits relevant to the production of gamma-band electroencephalography (EEG) signals but also modulates these networks without causing the widespread disturbances in brain function often associated with ketamine [1]. In a study involving male Sprague-Dawley rats, lanicemine was shown to significantly elevate spontaneous gamma-band EEG activities in a dose-dependent manner, distinguishing it from ketamine, whose effects on gamma EEG changes were closely linked with increased locomotor activity [1].