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(S,R,S)-AHPC-C2-PEG4-N3

Name: (S,R,S)-AHPC-C2-PEG4-N3
Brand: TargetMol
SKU: T18662
Price: 386 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T18662

Alias VH032-C2-PEG4-N3

(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that combines the (S,R,S)-AHPC-based VHL ligand with a 4-unit polyethylene glycol (PEG) linker, used in PROteolysis TAgeting Chimera (PROTAC) technology. This compound aids in the formation of vRucaparib-TP4, a potent PARP1 degrader with a half-maximal degrading concentration (DC50) of 82 nM[1].

(S,R,S)-AHPC-C2-PEG4-N3

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Catalog No. T18662Alias VH032-C2-PEG4-N3

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500 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that combines the (S,R,S)-AHPC-based VHL ligand with a 4-unit polyethylene glycol (PEG) linker, used in PROteolysis TAgeting Chimera (PROTAC) technology. This compound aids in the formation of vRucaparib-TP4, a potent PARP1 degrader with a half-maximal degrading concentration (DC50) of 82 nM[1].
Alias	VH032-C2-PEG4-N3

Chemical Properties

Molecular Weight	703.85
Formula	C₃₃H₄₉N₇O₈S
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(S,R,S)AHPCC2PEG4N3(S,R,S) AHPC C2 PEG4 N3AHPC-C2-PEG4-N3(S,R,S)-AHPC-C-2-PEG4-N3