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(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized conjugate comprising an E3 ligase ligand-linker and a VH032-based VHL ligand, commonly used in PROTAC technology. This compound is essential in synthesizing various PROTACs, such as UNC6852, a bivalent chemical degrader that specifically targets EED [1].
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Description | (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized conjugate comprising an E3 ligase ligand-linker and a VH032-based VHL ligand, commonly used in PROTAC technology. This compound is essential in synthesizing various PROTACs, such as UNC6852, a bivalent chemical degrader that specifically targets EED [1]. |
In vitro | PROTACs comprise two distinct ligands joined by a linker: one targets an E3 ubiquitin ligase and the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. [PROTACs] |
Alias | VH032-C3-NH2 |
Molecular Weight | 515.67 |
Formula | C26H37N5O4S |
Cas No. | 2361119-88-0 |
Relative Density. | 1.242 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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