(S,R,S)-AHPC-C5-COOH

(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized conjugate for E3 ligase ligand-linker applications, combining the VH032 VHL-based ligand with a linker for PROTAC development. VH-032 is a selective and potent VHL/HIF-1α interaction inhibitor with a dissociation constant (Kd) of 185 nM, offering potential in anemia and ischemic diseases research[1].

Catalog No. T18667Cas No. 2267282-19-7

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(S,R,S)-AHPC-C5-COOH

Catalog No. T18667Cas No. 2267282-19-7

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Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized conjugate for E3 ligase ligand-linker applications, combining the VH032 VHL-based ligand with a linker for PROTAC development. VH-032 is a selective and potent VHL/HIF-1α interaction inhibitor with a dissociation constant (Kd) of 185 nM, offering potential in anemia and ischemic diseases research[1].
In vitro	PROTACs are bifunctional molecules consisting of two ligands linked together; one binds to an E3 ubiquitin ligase, and the other targets a specific protein. Through the utilization of the cell's ubiquitin-proteasome system, PROTACs achieve the selective degradation of target proteins. Notably, the von Hippel–Lindau (VHL) tumor suppressor protein functions as the substrate-binding component of the VHL E3 ubiquitin ligase, targeting the hydroxylated α subunit of hypoxia-inducible factors (HIFs) for ubiquitination and subsequent proteasomal degradation.
Alias	VH032-C5-COOH

Chemical Properties

Molecular Weight	558.73
Formula	C₂₉H₄₂N₄O₅S
Cas No.	2267282-19-7

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Keywords

(S,R,S) AHPC C5 COOH(S,R,S)-AHPC-C-5-COOHAHPC-C5-COOH(S,R,S)AHPCC5COOH