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(S,R,S)-AHPC-C6-PEG3-C4-Cl

(S,R,S)-AHPC-C6-PEG3-C4-Cl
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(S,R,S)-AHPC-C6-PEG3-C4-Cl

Catalog No. T17911Cas No. 1835705-55-9
(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$615 days
5 mg$98Backorder
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Product Introduction

Bioactivity
Description
(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
In vitro
The chemical compound '(S,R,S)-AHPC-C6-PEG3-C4-Cl' utilizes the cereblon ligand[1] and features a 6-2-2-6 linker, incorporating both hydrophobic and hydrophilic elements to achieve a balanced hydrophilicity/hydrophobicity in the resultant compounds. This compound forms the basis for developing PROTACs aimed at degrading the oncogenic tyrosine kinase BCR-ABL. It is engineered to attach to potent TKIs, specifically bosutinib and dasatinib, facilitating the degradation of c-ABL and BCR-ABL by exploiting either CRBN or VHL E3 ubiquitin ligase mechanisms[2].
AliasVH032-C6-PEG3-C4-Cl, VHL Ligand-Linker Conjugates 12, E3 ligase Ligand-Linker Conjugates 8
Chemical Properties
Molecular Weight751.42
FormulaC38H59ClN4O7S
Cas No.1835705-55-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 100 mg/mL (133.08 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3308 mL6.6541 mL13.3081 mL66.5407 mL
5 mM0.2662 mL1.3308 mL2.6616 mL13.3081 mL
10 mM0.1331 mL0.6654 mL1.3308 mL6.6541 mL
20 mM0.0665 mL0.3327 mL0.6654 mL3.3270 mL
50 mM0.0266 mL0.1331 mL0.2662 mL1.3308 mL
100 mM0.0133 mL0.0665 mL0.1331 mL0.6654 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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