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(S,R,S)-AHPC-PEG2-C4-Cl

Catalog No. T17910Cas No. 1835705-57-1

(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

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Pack Size	Price	Availability	Quantity
2 mg	$61	5 days
5 mg	$98	Backorder

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Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
In vitro	(S,R,S)-AHPC-PEG2-C4-Cl employs the VHL ligand to facilitate the development of PROTACs targeting the oncogenic tyrosine kinase, BCR-ABL, through the utilization of a 6-2-2 linker which incorporates both hydrophobic and hydrophilic elements to optimize the hybrid compounds' balance of hydrophobicity and hydrophilicity. Moreover, this compound can be conjugated with potent tyrosine kinase inhibitors (TKIs), specifically bosutinib and dasatinib, to promote the degradation of c-ABL and BCR-ABL by exploiting either CRBN or VHL E3 ubiquitin ligase mechanisms.
Alias	E3 ligase Ligand-Linker Conjugates 10, VHL Ligand-Linker Conjugates 7, VH032-PEG2-C4-Cl

Chemical Properties

Molecular Weight	651.26
Formula	C32H47ClN4O6S
Cas No.	1835705-57-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (76.77 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5355 mL	7.6774 mL	15.3549 mL	76.7743 mL
5 mM	0.3071 mL	1.5355 mL	3.0710 mL	15.3549 mL
10 mM	0.1535 mL	0.7677 mL	1.5355 mL	7.6774 mL
20 mM	0.0768 mL	0.3839 mL	0.7677 mL	3.8387 mL
50 mM	0.0307 mL	0.1535 mL	0.3071 mL	1.5355 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc