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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $61 | 5 days | |
5 mg | $98 | Backorder |
Description | (S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. |
In vitro | (S,R,S)-AHPC-PEG2-C4-Cl employs the VHL ligand to facilitate the development of PROTACs targeting the oncogenic tyrosine kinase, BCR-ABL, through the utilization of a 6-2-2 linker which incorporates both hydrophobic and hydrophilic elements to optimize the hybrid compounds' balance of hydrophobicity and hydrophilicity. Moreover, this compound can be conjugated with potent tyrosine kinase inhibitors (TKIs), specifically bosutinib and dasatinib, to promote the degradation of c-ABL and BCR-ABL by exploiting either CRBN or VHL E3 ubiquitin ligase mechanisms. |
Alias | E3 ligase Ligand-Linker Conjugates 10, VHL Ligand-Linker Conjugates 7, VH032-PEG2-C4-Cl |
Molecular Weight | 651.26 |
Formula | C32H47ClN4O6S |
Cas No. | 1835705-57-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (76.77 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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