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(S,R,S)-AHPC-PEG4-NH2 hydrochloride

Catalog No. T15190Cas No. 2064292-52-8
Alias VHL Ligand-Linker Conjugates 4 hydrochloride, VH032-PEG4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 7

(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.

(S,R,S)-AHPC-PEG4-NH2 hydrochloride
Other Forms of (S,R,S)-AHPC-PEG4-NH2 hydrochloride:
(S,R,S)-AHPC-PEG4-NH2T15190L2010159-57-4
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(S,R,S)-AHPC-PEG4-NH2 hydrochloride

Catalog No. T15190Alias VHL Ligand-Linker Conjugates 4 hydrochloride, VH032-PEG4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 7Cas No. 2064292-52-8
(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.
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2 mg$315 days
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Product Introduction

Bioactivity
Description
(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.
In vitro
Extracted from the patent US20170008904A1, '(S,R,S)-AHPC-PEG4-NH2 hydrochloride' serves as a reagent for synthesizing 'compound A1895' as demonstrated in example 3[1].
AliasVHL Ligand-Linker Conjugates 4 hydrochloride, VH032-PEG4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 7
Chemical Properties
Molecular Weight700.29
FormulaC32H50ClN5O8S
Cas No.2064292-52-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (71.40 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.4280 mL7.1399 mL14.2798 mL71.3990 mL
5 mM0.2856 mL1.4280 mL2.8560 mL14.2798 mL
10 mM0.1428 mL0.7140 mL1.4280 mL7.1399 mL
20 mM0.0714 mL0.3570 mL0.7140 mL3.5699 mL
50 mM0.0286 mL0.1428 mL0.2856 mL1.4280 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

VH032-PEG4-NH2 Hydrochloride(S,R,S) AHPC PEG4 NH2 hydrochlorideVHL Ligand-Linker Conjugates 4 Hydrochloride(S,R,S)AHPCPEG4NH2 hydrochloride(S,R,S)-AHPC-PEG-4-NH2 hydrochlorideAHPC-PEG4-NH2 Hydrochloride
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