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(S,R,S)-AHPC-PEG4-NH2 hydrochloride

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Catalog No. T15190Cas No. 2064292-52-8
Alias VHL Ligand-Linker Conjugates 4 hydrochloride, VH032-PEG4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 7

(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.

(S,R,S)-AHPC-PEG4-NH2 hydrochloride

(S,R,S)-AHPC-PEG4-NH2 hydrochloride

😃Good
Catalog No. T15190Alias VHL Ligand-Linker Conjugates 4 hydrochloride, VH032-PEG4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 7Cas No. 2064292-52-8
(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.
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2 mg$315 days
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Product Introduction

Bioactivity
Description
(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.
In vitro
Extracted from the patent US20170008904A1, '(S,R,S)-AHPC-PEG4-NH2 hydrochloride' serves as a reagent for synthesizing 'compound A1895' as demonstrated in example 3[1].
AliasVHL Ligand-Linker Conjugates 4 hydrochloride, VH032-PEG4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 7
Chemical Properties
Molecular Weight700.29
FormulaC32H50ClN5O8S
Cas No.2064292-52-8
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (71.40 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.4280 mL7.1399 mL14.2798 mL71.3990 mL
5 mM0.2856 mL1.4280 mL2.8560 mL14.2798 mL
10 mM0.1428 mL0.7140 mL1.4280 mL7.1399 mL
20 mM0.0714 mL0.3570 mL0.7140 mL3.5699 mL
50 mM0.0286 mL0.1428 mL0.2856 mL1.4280 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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