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(S,R,S)-AHPC-PEG6-C4-Cl

(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC comprising the (S,R,S)-AHPC based VHL ligand and a 6-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

Catalog No. T17926Cas No. 1835705-59-3

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(S,R,S)-AHPC-PEG6-C4-Cl

Catalog No. T17926Cas No. 1835705-59-3

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
2 mg	$61	5 days
5 mg	$98	Backorder

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Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC comprising the (S,R,S)-AHPC based VHL ligand and a 6-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
In vitro	HaloPROTACs are engineered to facilitate the ubiquitylation and subsequent degradation of HaloTag7 fusion proteins[1].
Alias	VHL Ligand-Linker Conjugates 10, E3 ligase Ligand-Linker Conjugates 9, VH032-PEG6-C4-Cl

Chemical Properties

Molecular Weight	827.47
Formula	C₄₀H₆₃ClN₄O₁₀S
Cas No.	1835705-59-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (120.85 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2085 mL	6.0425 mL	12.0850 mL	60.4252 mL
5 mM	0.2417 mL	1.2085 mL	2.4170 mL	12.0850 mL
10 mM	0.1209 mL	0.6043 mL	1.2085 mL	6.0425 mL
20 mM	0.0604 mL	0.3021 mL	0.6043 mL	3.0213 mL
50 mM	0.0242 mL	0.1209 mL	0.2417 mL	1.2085 mL
100 mM	0.0121 mL	0.0604 mL	0.1209 mL	0.6043 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(S,R,S)AHPCPEG6C4Cl(S,R,S)-AHPC-PEG-6-C4-ClAHPC-PEG6-C4-Cl(S,R,S) AHPC PEG6 C4 Cl