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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | α-Glucosidase-IN-21 (Compound 2B) is a highly potent and orally bioavailable inhibitor of α-glucosidase. With an impressive IC50 value of 2.62 μM, this compound exhibits remarkable anti-diabetic properties [1]. |
In vivo | α-Glucosidase-IN-21 (Compound 2B), administered orally at dosages of 10 and 20 mg/kg daily for four weeks, demonstrates anti-diabetic efficacy in male Wistar albino rats (170-200 g) with Streptozocin-induced diabetes. This compound significantly reduces serum glucose levels post-glucose administration (3 g/kg, orally) and shows no mortality in mice at a higher dosage of 2000 mg/kg over two weeks. Moreover, α-Glucosidase-IN-21 effectively decreases blood glucose levels, counteracts Streptozocin-induced weight loss, and exhibits antihyperlipidemic properties by notably lowering serum biomarkers in the diabetic rat model. |
Molecular Weight | 389.51 |
Formula | C24H23NO2S |
Cas No. | 321686-01-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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