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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,140 | 6-8 weeks | |
50 mg | $2,785 | 6-8 weeks | |
100 mg | $3,520 | 6-8 weeks |
Description | α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β and IL-1β in murine macrophages RAW264.7. α7 nAchR-JAK2-STAT3 agonist 1 was effective in inhibiting the expression of iNOS, IL-1β and IL-6 in mouse macrophages. α7 nAchR-JAK2-STAT3 agonist 1 inhibited LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 agonist 1 was able to be used to study sepsis. |
Molecular Weight | 426.5 |
Formula | C25H30O6 |
Cas No. | 2108714-20-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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