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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $71 | Backorder | |
5 mg | $220 | Backorder | |
10 mg | $331 | Backorder |
Description | β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol Sin. 2017 Sep;38(9):1205-1235. |
In vitro | β-Amyloid (1-14),mouse,rat is generated via the proteolytic cleavage of the transmembrane amyloid precursor protein (APP) by β- and γ-secretases. Accumulation of β-Amyloid (1-14),mouse,rat in the brain is believed to be an initial toxic occurrence in Alzheimer’s disease development, the prevalent dementia form characterized by brain plaques and tangles[1]. |
Cas No. |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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