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β-Apo-13-carotenone

β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.

Catalog No. T13431Cas No. 17974-57-1

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β-Apo-13-carotenone

Catalog No. T13431Cas No. 17974-57-1

β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.

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Product Introduction

Bioactivity

Description	β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.
In vitro	In homogenates of intestinal mucosa of rat, β-apo-13-Carotenone is identified as enzymatic cleavage products of β-carotene. β-apo-13-carotenone is antagonize the activation of RXRα by 9-cis-retinoic acid and is effective at concentrations as low as 1nM. Molecular modeling studies reveal that β-apo-13-carotenone makes molecular interactions like an antagonist of RXRα[1]. β-apo-13-carotenone competes for 9cRA binding to RXRα with an affinity (7–8 nM) identical to 9cRA itself. β-apo-13-carotenone antagonizes 9cRA activation of full-length hRXRα with a similar efficiency as the known antagonist UVI3003. β-apo-13-carotenone induces formation of the RXRα transcriptionally silent tetramer but does not inhibit coactivator recruitment to the isolated LBD[2].
Alias	D'Orenone

Chemical Properties

Molecular Weight	258.4
Formula	C₁₈H₂₆O
Cas No.	17974-57-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 33.33 mg/mL (128.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8700 mL	19.3498 mL	38.6997 mL	193.4985 mL
5 mM	0.7740 mL	3.8700 mL	7.7399 mL	38.6997 mL
10 mM	0.3870 mL	1.9350 mL	3.8700 mL	19.3498 mL
20 mM	0.1935 mL	0.9675 mL	1.9350 mL	9.6749 mL
50 mM	0.0774 mL	0.3870 mL	0.7740 mL	3.8700 mL
100 mM	0.0387 mL	0.1935 mL	0.3870 mL	1.9350 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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