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β-Secretase Inhibitor IV
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Catalog No. T13434Cas No. 797035-11-1
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1, with IC50 values of 15.6 nM and 16.3 nM at BACE-1 concentrations of 2 nM and 100 pM, respectively.
β-Secretase Inhibitor IV
😃Good
Catalog No. T13434Cas No. 797035-11-1
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1, with IC50 values of 15.6 nM and 16.3 nM at BACE-1 concentrations of 2 nM and 100 pM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $335 | 35 days | |
| 1 mg | $633 | 35 days | |
| 5 mg | $2,480 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1, with IC50 values of 15.6 nM and 16.3 nM at BACE-1 concentrations of 2 nM and 100 pM, respectively. |
| Targets&IC50 | Cathepsin D:7620±210 nM , BACE2:230±26 nM , BACE1:15.3±0.6 nM |
| In vitro | β-Secretase Inhibitor IV (Compound 2) inhibits the production of Aβ peptides with an EC50 of 43 nM in the cell culture assay. β-Secretase Inhibitor IV potently suppresses the secretion of sAPP_NF and EV40 from HEK293T cells(IC50 : 30 nM). |
| Molecular Weight | 578.72 |
| Formula | C31H38N4O5S |
| Cas No. | 797035-11-1 |
| Relative Density. | 1.30 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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