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ω-Hydroxy-DEET
🥰Excellent
Catalog No. T40833Cas No. 72236-22-7
ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.
ω-Hydroxy-DEET
🥰Excellent
Catalog No. T40833Cas No. 72236-22-7
ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.
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Product Introduction
Bioactivity
Chemical Properties
| Description | ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact. |
| In vitro | Studies on hepatoma cells demonstrate that treatment with ω-Hydroxy-DEET (DHMB; at concentrations ranging from 0.1 to 10 μg/mL for durations of 48 to 72 hours) leads to decreased cellular proliferation [1]. |
| In vivo | Following both intravenous and topical administration of DEET in rats, the metabolite ω-Hydroxy-DEET (DHMB) showed extensive distribution, with ω-Hydroxy-DEET emerging as DEET's principal metabolite. Notably, repeated daily topical applications over a 30-day period resulted in elevated ω-Hydroxy-DEET concentrations in the liver[1]. |
| Molecular Weight | 207.27 |
| Formula | C12H17NO2 |
| Cas No. | 72236-22-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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