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(1R,2R)-ML-SI3

Name: (1R,2R)-ML-SI3
Brand: TargetMol
SKU: T62378
Price: 233 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62378Cas No. 2418594-00-8

Alias (-)-trans-ML-SI3

(1R,2R)-ML-SI3 ((-)-trans-ML-SI3) is a selective TRPML1, TRPML2, and TRPML3 inhibitor for the study of neurodegenerative and cardiovascular diseases.

(1R,2R)-ML-SI3

😃Good

Catalog No. T62378Alias (-)-trans-ML-SI3Cas No. 2418594-00-8

(1R,2R)-ML-SI3 ((-)-trans-ML-SI3) is a selective TRPML1, TRPML2, and TRPML3 inhibitor for the study of neurodegenerative and cardiovascular diseases.

Pack Size	Price	Availability
2 mg	$233	In Stock
25 mg	$1,110	6-8 weeks
50 mg	$1,450	6-8 weeks
100 mg	$2,320	6-8 weeks

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	(1R,2R)-ML-SI3 ((-)-trans-ML-SI3) is a selective TRPML1, TRPML2, and TRPML3 inhibitor for the study of neurodegenerative and cardiovascular diseases.
Targets&IC50	TRPML3:12.5 μM, TRPML2:2.3 μM, TRPML1:1.6 μM
In vitro	(1R,2R)-ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of all three TRPML isoforms. (1R,2R)-ML-SI3 was a potent inhibitor of TRPML1 (IC50=1.6 μM), TRPML2 (IC50=2.3 μM) and TRPML3 (IC50=12.5 μM), (1R,2R)-ML-SI3 was a potent inhibitor of TRPML1 and TRPML2 and a weak inhibitor of TRPML3. [1]
Alias	(-)-trans-ML-SI3

Chemical Properties

Molecular Weight	429.58
Formula	C₂₃H₃₁N₃O₃S
Cas No.	2418594-00-8
Smiles	N(S(=O)(=O)C1=CC=CC=C1)[C@H]2[C@@H](CCCC2)N3CCN(CC3)C4=C(OC)C=CC=C4

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL(186.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3279 mL	11.6393 mL	23.2786 mL	116.3928 mL
5 mM	0.4656 mL	2.3279 mL	4.6557 mL	23.2786 mL
10 mM	0.2328 mL	1.1639 mL	2.3279 mL	11.6393 mL
20 mM	0.1164 mL	0.5820 mL	1.1639 mL	5.8196 mL
50 mM	0.0466 mL	0.2328 mL	0.4656 mL	2.3279 mL
100 mM	0.0233 mL	0.1164 mL	0.2328 mL	1.1639 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc