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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,220 | 6-8 weeks | |
50 mg | $1,590 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | (R)-Posenacaftor ((R)-PTI-801) sodium, the R enantiomer of Posenacaftor, is a cystic fibrosis transmembrane regulator (CFTR) protein modulator. It corrects the folding and trafficking of the CFTR protein, and is utilized in the research of cystic fibrosis (CF)[1]. |
In vitro | Cystic fibrosis (CF) is an autosomal recessive disorder resulting from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene[1]. These mutations cause the CFTR protein, a cAMP-regulated chloride channel primarily found on the epithelial cells' apical membrane, to be defective and misfolded, disrupting ion flow across cell membranes[1]. Posenacaftor acts as a CFTR corrector, designed to repair and restore the defective CFTR protein's function. Once corrected, the CFTR protein is transported to the cell surface, where it resumes its role as a chloride channel, aiding in the regulation of fluid balance in the airways[2]. |
Molecular Weight | 468.505 |
Formula | C27H27NNaO5 |
Cas No. | 2095064-09-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 38.33 mg/mL (81.99 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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