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Guanethidine
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Catalog No. T50109Cas No. 55-65-2
Guanethidine sulphate, synthesized in 1959, is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.
Guanethidine
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Catalog No. T50109Cas No. 55-65-2
Guanethidine sulphate, synthesized in 1959, is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | Inquiry | 6-8 weeks | |
| 500 mg | Inquiry | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Guanethidine sulphate, synthesized in 1959, is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres. |
| In vitro | Sympathetic fibers ablation is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro [1]. |
| In vivo | Guanethidine (30 mg/kg, s.c., 1 h) administration does not alter IL-18 induced hypernociception in TNFR1 (-/-) mice, indicating that this sympathetic blocker is ineffective in this context [2]. This outcome was observed in a study involving WT Balb/c, TNFR1 (-/-), and IFN-γ (-/-) mice, with guanethidine diluted in saline. |
| Molecular Weight | 198.31 |
| Formula | C10H22N4 |
| Cas No. | 55-65-2 |
| Relative Density. | 1.13g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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