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11-trans Leukotriene C4

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Catalog No. T37492Cas No. 74841-69-3
Alias 11-trans Leukotriene C4

11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.

11-trans Leukotriene C4
Other Forms of 11-trans Leukotriene C4:
Leukotriene C4T2568772025-60-6
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11-trans Leukotriene C4

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Catalog No. T37492Alias 11-trans Leukotriene C4Cas No. 74841-69-3
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.
Pack SizePriceAvailabilityQuantity
25 μg392 €35 days
50 μg743 €35 days
100 μg1.406 €35 days
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Product Introduction

Bioactivity
Description
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.
Alias11-trans Leukotriene C4
Chemical Properties
Molecular Weight625.78
FormulaC30H47N3O9S
Cas No.74841-69-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: >50 mg/mL (per Ramki Iyer)
PBS (pH 7.2): >100 μg/mL (per Ramki Iyer)
Ethanol: >50 mg/mL (per Ramki Iyer)
DMF: >50 mg/mL (per Ramki Iyer)

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Keywords

11trans Leukotriene C411-trans Leukotriene C-411 trans Leukotriene C4
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