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TOPBioactivityChemical infoStorage&SolubilityCalculatorReferences

13(S)-HpOTrE(γ)

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Catalog No. T37395Cas No. 121107-97-9

13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE. At concentrations greater than 100 μM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.

13(S)-HpOTrE(γ)

13(S)-HpOTrE(γ)

😃Good
Catalog No. T37395Cas No. 121107-97-9
13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE. At concentrations greater than 100 μM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.
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100 μg$198 35 days
500 μg$890 35 days
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Questions
QWhat’s Kd?
ADissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
QWhat’s IC50?
AHalf-maximal inhibitory concentration (IC50) refers to the concentration of the inhibitor which is required to inhibit a given biological or biochemical function by half.
QWhat’s EC50?
AHalf maximal effective concentratioin(EC50) refers to the concentration of a compound that achieves 50% of the maximum effect(inhibitory/stimulatory effect),after a specified exposure duration.
QDoes the compound differ in any way when it is in the form of hydrochloride or sulfate ions? What is the difference between the salt form and the free form?
AThe molecules in salt and non-salt forms exhibit the same activity, and they have consistent effects in biological experiments. Their activity and usage are identical. The only difference lies in their salt forms, which may result in variations in physical properties such as solubility. It is recommended to choose based on solubility and experimental requirements.
QWhat’s ED50?
AEffective dose 50 (ED50）refers to the dose of a drug that produces a specific effect in 50% of the population that has been administered that dose.
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Product Introduction

Bioactivity
Description
13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE. At concentrations greater than 100 μM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.
Chemical Properties
Molecular Weight310.43
FormulaC18H30O4
Cas No.121107-97-9
Relative Density.1.016 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: >50 mg/mL (per Rao Maddipati), Sonication is recommended.
PBS (pH 7.2): >1 mg/mL (from 13(S)-HODE), Sonication is recommended.
DMF: >50 mg/mL (per Rao Maddipati), Sonication is recommended.
Ethanol: >50 mg/mL (per Rao Maddipati), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Dose Conversion

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References

1.Kuroda A, Sakai K, Yahagi S, Mukawa T, Sato N, Nakamura N, Maezawa D, Masaki H, Banno T, Asakura K. Surface Structures of Cosmetic Standard Poly Methyl Methacrylate UV Evaluation Plates and their Influence on the in vitro Evaluation of UV Protection Abilities of Cosmetic Sunscreens. J Oleo Sci. 2019 Feb 1;68(2):175-182. doi: 10.5650/jos.ess18207. Epub 2019 Jan 17. PubMed PMID: 30651410.2.Ghidotti M, Fabbri D, Torri C. Determination of linear and cyclic volatile methyl siloxanes in biogas and biomethane by solid-phase microextraction and gas chromatography-mass spectrometry. Talanta. 2019 Apr 1;195:258-264. doi: 10.1016/j.talanta.2018.11.032. Epub 2018 Nov 13. PubMed PMID: 30625541.3.Helm JS, Nishioka M, Brody JG, Rudel RA, Dodson RE. Re: Measurement of endocrine disrupting and asthma-associated chemicals in hair products used by Black women. Environ Res. 2018 Dec 3. pii: S0013-9351(18)30611-X. doi: 10.1016/j.envres.2018.11.029. [Epub ahead of print] PubMed PMID: 30616861.4.Guo J, Zhou Y, Zhang B, Zhang J. Distribution and evaluation of the fate of cyclic volatile methyl siloxanes in the largest lake of southwest China. Sci Total Environ. 2019 Mar 20;657:87-95. doi: 10.1016/j.scitotenv.2018.11.454. Epub 2018 Dec 4. PubMed PMID: 30530222.

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

13HpOTrE(gamma)13(S) HpOTrE(γ)13HpOTrE(r)13(S)HpOTrE(γ)13HpOTrE(γ)
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