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15-keto-17-phenyl trinor Prostaglandin F2α

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Catalog No. T37934Cas No. 949564-89-0
Alias 15-keto-17-phenyl trinor Prostaglandin F2α

Bimatoprost is an F-series prostaglandin (PG) analog approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α, a potential metabolite when administered to animals. 15-keto PG analogs can be minor impurities in commercial preparations of corresponding bulk drug compounds. Although much less potent than the parent compound, 15-keto PGs can still produce a small but measurable decrease (1 mm Hg) in intraocular pressure of normal cynomolgus monkeys at a dose of 1 μg/eye. 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) acts as a miotic in normal cat eyes, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. This is less potent compared to many other F-type PGs; for example, PGF2α induces similar miosis at less than 1 μg/eye.

15-keto-17-phenyl trinor Prostaglandin F2α

15-keto-17-phenyl trinor Prostaglandin F2α

😃Good
Catalog No. T37934Alias 15-keto-17-phenyl trinor Prostaglandin F2αCas No. 949564-89-0
Bimatoprost is an F-series prostaglandin (PG) analog approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α, a potential metabolite when administered to animals. 15-keto PG analogs can be minor impurities in commercial preparations of corresponding bulk drug compounds. Although much less potent than the parent compound, 15-keto PGs can still produce a small but measurable decrease (1 mm Hg) in intraocular pressure of normal cynomolgus monkeys at a dose of 1 μg/eye. 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) acts as a miotic in normal cat eyes, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. This is less potent compared to many other F-type PGs; for example, PGF2α induces similar miosis at less than 1 μg/eye.
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1 mg$16035 days
5 mg$68635 days
10 mg$1,24035 days
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Product Introduction

Bioactivity
Description
Bimatoprost is an F-series prostaglandin (PG) analog approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α, a potential metabolite when administered to animals. 15-keto PG analogs can be minor impurities in commercial preparations of corresponding bulk drug compounds. Although much less potent than the parent compound, 15-keto PGs can still produce a small but measurable decrease (1 mm Hg) in intraocular pressure of normal cynomolgus monkeys at a dose of 1 μg/eye. 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) acts as a miotic in normal cat eyes, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. This is less potent compared to many other F-type PGs; for example, PGF2α induces similar miosis at less than 1 μg/eye.
Alias15-keto-17-phenyl trinor Prostaglandin F2α
Chemical Properties
Molecular Weight386.488
FormulaC23H30O5
Cas No.949564-89-0
Relative Density.1.216 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
PBS (pH 7.2): 2.5 mg/mL
DMF: 30 mg/mL
DMSO: 25 mg/mL
Ethanol: 30 mg/mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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