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16(S)-Iloprost

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Catalog No. T36212Cas No. 74843-14-4

Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(S)-Iloprost potently inhibits platelet aggregation with an IC50 value of 3.5 nM.

16(S)-Iloprost
Other Forms of 16(S)-Iloprost:

16(S)-Iloprost

😃Good
Catalog No. T36212Cas No. 74843-14-4
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(S)-Iloprost potently inhibits platelet aggregation with an IC50 value of 3.5 nM.
Pack SizePriceAvailabilityQuantity
500 μg$560 35 days
1 mg$1,060 35 days
5 mg$4,440 35 days
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Product Introduction

Bioactivity
Description
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(S)-Iloprost potently inhibits platelet aggregation with an IC50 value of 3.5 nM.
Chemical Properties
Molecular Weight360.49
FormulaC22H32O4
Cas No.74843-14-4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 30 mg/mL (83.22 mM), Sonication is recommended.
Ethanol: 30 mg/mL (83.22 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.77 mM), Sonication is recommended.
DMSO: 25 mg/mL (69.35 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM2.7740 mL13.8700 mL27.7400 mL138.7001 mL
DMSO/DMF/Ethanol
1mg5mg10mg50mg
5 mM0.5548 mL2.7740 mL5.5480 mL27.7400 mL
10 mM0.2774 mL1.3870 mL2.7740 mL13.8700 mL
20 mM0.1387 mL0.6935 mL1.3870 mL6.9350 mL
50 mM0.0555 mL0.2774 mL0.5548 mL2.7740 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

16(S) Iloprost16Iloprost16(S)Iloprost
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