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17-phenyl trinor Prostaglandin E2 ethyl amide

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Catalog No. T37996Cas No. 1219032-20-8
Alias 17-phenyl trinor Prostaglandin E2 ethyl amide

17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to increase lipid solubility, thereby improving uptake into tissues and further lowering the effective concentration. Ethyl amide groups are then removed by amidases, regenerating the active free acid.

17-phenyl trinor Prostaglandin E2 ethyl amide

17-phenyl trinor Prostaglandin E2 ethyl amide

😃Good
Catalog No. T37996Alias 17-phenyl trinor Prostaglandin E2 ethyl amideCas No. 1219032-20-8
17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to increase lipid solubility, thereby improving uptake into tissues and further lowering the effective concentration. Ethyl amide groups are then removed by amidases, regenerating the active free acid.
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1 mg$235 35 days
5 mg$987 35 days
10 mg$1,840 35 days
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Product Introduction

Bioactivity
Description
17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to increase lipid solubility, thereby improving uptake into tissues and further lowering the effective concentration. Ethyl amide groups are then removed by amidases, regenerating the active free acid.
Alias17-phenyl trinor Prostaglandin E2 ethyl amide
Chemical Properties
Molecular Weight413.55
FormulaC25H35NO4
Cas No.1219032-20-8
Relative Density.1.141 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 100 mg/mL (241.81 mM), Sonication is recommended.
PBS (pH 7.2): 0.5 mg/mL (1.21 mM), Sonication is recommended.
Ethanol: 100 mg/mL (241.81 mM), Sonication is recommended.
DMSO: 100 mg/mL (241.81 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMF/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.4181 mL12.0904 mL24.1809 mL120.9044 mL
DMF/Ethanol/DMSO
1mg5mg10mg50mg
5 mM0.4836 mL2.4181 mL4.8362 mL24.1809 mL
10 mM0.2418 mL1.2090 mL2.4181 mL12.0904 mL
20 mM0.1209 mL0.6045 mL1.2090 mL6.0452 mL
50 mM0.0484 mL0.2418 mL0.4836 mL2.4181 mL
100 mM0.0242 mL0.1209 mL0.2418 mL1.2090 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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