Name: 2'-Deoxy-2'-fluoro-l-uridine
Brand: TargetMol
SKU: T74652
Rating: 4.5 (1 reviews)

2'-Deoxy-2'-fluoro-l-uridine

😃Good

Catalog No. T74652Cas No. 622785-69-7

2'-Deoxy-2'-fluoro-l-uridine, an L-nucleoside compound, is a potent and selective inhibitor of viral RNA polymerase, effectively inhibiting RNA virus replication [1].

Pack Size	Price	Availability	Quantity
5 mg	Inquiry	Backorder
50 mg	Inquiry	Backorder

Bulk & Custom

Add to Cart

QCan Tween-80 be used instead of Tween-20?

ATween-20 is not recommended. Tween-80 has better tolerance and has been used as a tool to assess the behavioral effects of experimental drugs and toxins without significant side effects. Reference: Castro CA, Hogan JB, Benson KA, Shehata CW, Landauer MR. Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620. Pharmacol Biochem Behav. 1995 Apr;50(4):521-6.

QHow to choose the appropriate solvent?

ACommon solvents include DMSO, water, ethanol, etc. Please select the appropriate solvent according to the solubility reference. If the inhibitor can be dissolved in DMSO, it is recommended to use freshly opened DMSO without moisture absorption. If the inhibitor can be dissolved in water, solvents like sterile water, physiological saline, sterile PBS ahd culture medium are recommended.

QWhat's the meaning of "< 1 mg/mL refers to the slightly soluble or insoluble"?

AIt means that if the solubility is less than 1 mg/mL

QCan inhibitors be used for cell experiments?

AYes, our inhibitors can be used for cell/in vitro experiments. However, some compounds may not have literature supporting their use in cell experiments. In such cases, we cannot guarantee efficacy.

QWhat should I do if the IC50 obtained for cell killing are significantly different from that presented on the your website?

AThe IC50 you obtain refers to the cell proliferation inhibition assay (half maximal inhibitory concentration), which is different in meaning from the IC50 on our website. The IC50 often refers to the inhibition rate of the target without cell experiments, which is generally determined through kinase or protein purification experiments, and is commonly reported in nanomolar concentrations. However, the IC50 obtained from cell proliferation inhibition assays refers to the half-maximal lethality of the cells, which involves cellular metabolism and penetration, so the concentration is usually higher. Furthermore, the effect of the same compound on different cell models varies. It is recommended to try increasing the incubation volume and extending the incubation time.

Product Introduction

Bioactivity

Description

2'-Deoxy-2'-fluoro-l-uridine, an L-nucleoside compound, is a potent and selective inhibitor of viral RNA polymerase, effectively inhibiting RNA virus replication [1].

Chemical Properties

Molecular Weight	246.19
Formula	C₉H₁₁FN₂O₅
Cas No.	622785-69-7

Storage & Solubility Information

Storage

Shipping with blue ice.

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.