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2-(Isopentylamino)naphthalene-1,4-dione

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Catalog No. T37950Cas No. 1607447-79-9

2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, respectively). It also protects mice against seizures in the 6 Hz psychomotor seizure test (ED50s = 152.7 and 263.7 mg/kg at stimulus intensities of 32 and 44 mA, respectively).

2-(Isopentylamino)naphthalene-1,4-dione

2-(Isopentylamino)naphthalene-1,4-dione

😃Good
Catalog No. T37950Cas No. 1607447-79-9
2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, respectively). It also protects mice against seizures in the 6 Hz psychomotor seizure test (ED50s = 152.7 and 263.7 mg/kg at stimulus intensities of 32 and 44 mA, respectively).
Pack SizePriceAvailabilityQuantity
1 mg$110 35 days
5 mg$394 35 days
10 mg$695 35 days
25 mg$1,460 35 days
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Product Introduction

Bioactivity
Description
2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, respectively). It also protects mice against seizures in the 6 Hz psychomotor seizure test (ED50s = 152.7 and 263.7 mg/kg at stimulus intensities of 32 and 44 mA, respectively).
1.Li, X., Himes, R.A., Prosser, L.C., et al.Discovery of the first vitamin K analogue as a potential treatment of pharmacoresistant seizuresJ. Med. Chem.63(11)5865-5878(2020)
Chemical Properties
Molecular Weight243.306
FormulaC15H17NO2
Cas No.1607447-79-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (123.3 mM), Sonication is recommended.
DMF: 30 mg/mL (123.3 mM), Sonication is recommended.
DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL (1.36 mM), Sonication is recommended.
Ethanol: 20 mg/mL (82.2 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM0.8220 mL4.1101 mL8.2201 mL41.1005 mL
10 mM0.4110 mL2.0550 mL4.1101 mL20.5503 mL
20 mM0.2055 mL1.0275 mL2.0550 mL10.2751 mL
50 mM0.0822 mL0.4110 mL0.8220 mL4.1101 mL
DMSO/DMF
1mg5mg10mg50mg
100 mM0.0411 mL0.2055 mL0.4110 mL2.0550 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

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