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GEMSA
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Catalog No. T21843Cas No. 77482-44-1
GEMSA is a potent inhibitor of enkephalin convertase (Ki = 8.8 nM) with analgesic effects[1].
GEMSA
😃Good
Catalog No. T21843Cas No. 77482-44-1
GEMSA is a potent inhibitor of enkephalin convertase (Ki = 8.8 nM) with analgesic effects[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $458 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GEMSA is a potent inhibitor of enkephalin convertase (Ki = 8.8 nM) with analgesic effects[1]. |
| In vitro | GEMSA effectively inhibits the activation of TAFI and porcine CBB, along with preventing the extended lysis time observed in recombinant BAP without causing the lysis of APC fibronectin. Additionally, GEMSA demonstrates inhibition of the increased lysis time associated with porcine CPB, TAFI, and recombinant BAP, APC, exhibiting EC50 values of 0.34 μM, 100 μM, 115 μM, and 90 μM, respectively. |
| In vivo | GEMSA administered intracerebroventricularly (ICV) at a dose of 0.1μg/mg every 3 days results in a 75% elevation in both hypothalamic luteinizing hormone-releasing hormone and serum luteinizing hormone levels, alongside a 60% reduction in serum prolactin concentrations in rats [3]. |
| Molecular Weight | 235.26 |
| Formula | C7H13N3O4S |
| Cas No. | 77482-44-1 |
| Relative Density. | 1.59g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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