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2-Methylthio-AMP diTEA

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Catalog No. T37525Cas No. 1227193-98-7

2-Methylthio-AMP diTEA (2-MeSAMP) is a selective and direct antagonist of the P2Y12 receptor, effectively inhibiting ADP-dependent platelet aggregation[1][2][3].

2-Methylthio-AMP diTEA

2-Methylthio-AMP diTEA

😃Good
Catalog No. T37525Cas No. 1227193-98-7
2-Methylthio-AMP diTEA (2-MeSAMP) is a selective and direct antagonist of the P2Y12 receptor, effectively inhibiting ADP-dependent platelet aggregation[1][2][3].
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
2-Methylthio-AMP diTEA (2-MeSAMP) is a selective and direct antagonist of the P2Y12 receptor, effectively inhibiting ADP-dependent platelet aggregation[1][2][3].
In vitro
2-Methylthio-AMP (2-MeSAMP) diTEA inhibits agonist-mediated αIIbβ3 activation in platelets[1]. However, 2-methylthio-AMP (50 μM; for 5 minutes) diTEA does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. It also fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets, and does not elevate cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1].
Chemical Properties
Molecular Weight595.69
FormulaC23H46N7O7PS
Cas No.1227193-98-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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