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2-MPPA

🥰Excellent
Catalog No. T22497Cas No. 254737-29-6
Alias GPI-5693, GPI5693, 2MPPA

2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases.

2-MPPA

2-MPPA

🥰Excellent
Purity: 99.81%
Catalog No. T22497Alias GPI-5693, GPI5693, 2MPPACas No. 254737-29-6
2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases.
Pack SizePriceAvailabilityQuantity
1 mg$48 In Stock
5 mg$112 In Stock
10 mg$179 In Stock
25 mg$413 In Stock
50 mg$739 In Stock
100 mg$1,280 In Stock
500 mg$2,590 In Stock
1 mL x 10 mM (in DMSO)$123 In Stock
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Purity:99.81%
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Product Introduction

Bioactivity
Description
2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases.
Targets&IC50
GCP II:90 nM
In vitro
The application of 2-MPPA (1-20 μM) had no effect on the intrinsic membrane properties of CA3 pyramidal neurons recorded in vitro in whole-cell current clamp or voltage clamp mode. [3]
In vivo
2-MPPA (30 mg/kg intraperitoneally administered) increased jumping behavior in morphine-dependent mice.
Opioid-dependent mice treated with 2-MPPA (30 mg/kg, intraperitoneal injection) showed a large number of episodes of tooth trembling. [1]
2-MPPA (10, 30, or 100mg/kg orally) significantly alleviated dizoxepine (0.1mg/kg) -induced PPI deficits in mice in a dose-dependent manner. [2]
AliasGPI-5693, GPI5693, 2MPPA
Chemical Properties
Molecular Weight206.26
FormulaC8H14O4S
Cas No.254737-29-6
SmilesO=C(O)CCC(C(=O)O)CCCS
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 8 mg/mL (38.79 mM), Sonication is recommended.
DMSO: 80 mg/mL (387.86 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM4.8482 mL24.2412 mL48.4825 mL242.4125 mL
5 mM0.9696 mL4.8482 mL9.6965 mL48.4825 mL
10 mM0.4848 mL2.4241 mL4.8482 mL24.2412 mL
20 mM0.2424 mL1.2121 mL2.4241 mL12.1206 mL
DMSO
1mg5mg10mg50mg
50 mM0.0970 mL0.4848 mL0.9696 mL4.8482 mL
100 mM0.0485 mL0.2424 mL0.4848 mL2.4241 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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