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2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $48 | In Stock | |
5 mg | $112 | In Stock | |
10 mg | $179 | In Stock | |
25 mg | $413 | In Stock | |
50 mg | $739 | In Stock | |
100 mg | $1,280 | In Stock | |
500 mg | $2,590 | In Stock | |
1 mL x 10 mM (in DMSO) | $123 | In Stock |
Description | 2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases. |
Targets&IC50 | GCP II:90 nM |
In vitro | The application of 2-MPPA (1-20 μM) had no effect on the intrinsic membrane properties of CA3 pyramidal neurons recorded in vitro in whole-cell current clamp or voltage clamp mode. [3] |
In vivo | 2-MPPA (30 mg/kg intraperitoneally administered) increased jumping behavior in morphine-dependent mice. Opioid-dependent mice treated with 2-MPPA (30 mg/kg, intraperitoneal injection) showed a large number of episodes of tooth trembling. [1] 2-MPPA (10, 30, or 100mg/kg orally) significantly alleviated dizoxepine (0.1mg/kg) -induced PPI deficits in mice in a dose-dependent manner. [2] |
Alias | GPI-5693, GPI5693, 2MPPA |
Molecular Weight | 206.26 |
Formula | C8H14O4S |
Cas No. | 254737-29-6 |
Smiles | O=C(O)CCC(C(=O)O)CCCS |
Relative Density. | 1.31g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 8 mg/mL (38.79 mM), Sonication is recommended. DMSO: 80 mg/mL (387.86 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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