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Pomalidomide 4'-alkylC3-acid

Name: Pomalidomide 4'-alkylC3-acid
Brand: TargetMol
SKU: T40026
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T40026Cas No. 2225940-47-4

Alias 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry.

Pomalidomide 4'-alkylC3-acid

🥰Excellent

Purity: 99.57%

Catalog No. T40026Alias 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acidCas No. 2225940-47-4

Pack Size	Price	Availability
1 mg	$33	In Stock
2 mg	$46	In Stock
5 mg	$67	In Stock
10 mg	$94	In Stock
25 mg	$170	In Stock
50 mg	$256	In Stock
100 mg	$377	In Stock
200 mg	$536	In Stock

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Purity:99.57%

Resource Download

COA HNMR HPLC

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Product Introduction

Bioactivity

Description	Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry.
In vitro	Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino] s a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC3 linker with terminal acid ready for conjugation to a target protein ligand.
Alias	4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid

Chemical Properties

Molecular Weight	359.33
Formula	C₁₇H₁₇N₃O₆
Cas No.	2225940-47-4
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCC(O)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Butanoic acid, 4[[2(2,6dioxo3piperidinyl)2,3dihydro1,3dioxo1Hisoindol4yl]amino]Butanoic acid, 4 [[2 (2,6 dioxo 3 piperidinyl) 2,3 dihydro 1,3 dioxo 1H isoindol 4 yl]amino]