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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $78 | 35 days | |
5 mg | $273 | 35 days | |
10 mg | $458 | 35 days |
Description | 2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein , but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 μg/ml). |
Molecular Weight | 886.06 |
Formula | C43H73F6N5O7 |
Cas No. | 1609010-59-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: 50 mg/mL Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL Ethanol: 50 mg/mL DMF: 50 mg/mL |
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