Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

5α-Androst-16-en-3α-ol

😃Good
Catalog No. T37194Cas No. 1153-51-1

5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50= 0.4 μM).25α-Androst-16-en-3α-ol (0.1-1 μM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2and α2β2γ2subunit-containing GABAAreceptors.

5α-Androst-16-en-3α-ol

5α-Androst-16-en-3α-ol

😃Good
Catalog No. T37194Cas No. 1153-51-1
5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50= 0.4 μM).25α-Androst-16-en-3α-ol (0.1-1 μM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2and α2β2γ2subunit-containing GABAAreceptors.
Pack SizePriceAvailabilityQuantity
10 mg$143 35 days
50 mg$550 35 days
100 mg$825 35 days
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
Resource Download
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Product Introduction

Bioactivity
Description
5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50= 0.4 μM).25α-Androst-16-en-3α-ol (0.1-1 μM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2and α2β2γ2subunit-containing GABAAreceptors.In vivo, 5α-androst-16-en-3α-ol (5-10 mg/kg) decreases immobility time in the forced swim test in mice. It increases time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at doses ranging from 30 to 50 mg/kg. 5α-Androst-16-en-3α-ol protects against seizures induced by pentylenetetrazole or electroshock in mice (ED50s = 48.9 and 21.9 mg/kg, respectively).
1.Brooksbank, B.W., Brown, R., and Gustafsson, J.A.The detection of 5α-androst-16-en-3α-ol in human male axillary sweatExperientia30(8)864-865(1974) 2.Kaminski, R.M., Marini, H., Ortinski, P.I., et al.The pheromone androstenol (5α-androst-16-en-3α-ol) is a neurosteroid positive modulator of GABAA receptorsJ. Pharmacol. Exp. Ther.317(2)694-703(2006)
In vivo
In vivo, 5α-androst-16-en-3α-ol (5-10 mg/kg) decreases immobility time in the forced swim test in mice. It increases time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at doses ranging from 30 to 50 mg/kg. 5α-Androst-16-en-3α-ol protects against seizures induced by pentylenetetrazole or electroshock in mice (ED50s = 48.9 and 21.9 mg/kg, respectively).
Chemical Properties
Molecular Weight274.448
FormulaC19H30O
Cas No.1153-51-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 20 mg/mL (72.87 mM), Sonication is recommended.
Ethanol: 30 mg/mL (109.31 mM), Sonication is recommended.
DMSO: 10 mg/mL (36.44 mM), Sonication is recommended.
Solution Preparation Table
DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM3.6437 mL18.2184 mL36.4368 mL182.1839 mL
5 mM0.7287 mL3.6437 mL7.2874 mL36.4368 mL
10 mM0.3644 mL1.8218 mL3.6437 mL18.2184 mL
20 mM0.1822 mL0.9109 mL1.8218 mL9.1092 mL
DMF/Ethanol
1mg5mg10mg50mg
50 mM0.0729 mL0.3644 mL0.7287 mL3.6437 mL
Ethanol
1mg5mg10mg50mg
100 mM0.0364 mL0.1822 mL0.3644 mL1.8218 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy 5α-Androst-16-en-3α-ol | purchase 5α-Androst-16-en-3α-ol | 5α-Androst-16-en-3α-ol cost | order 5α-Androst-16-en-3α-ol | 5α-Androst-16-en-3α-ol chemical structure | 5α-Androst-16-en-3α-ol in vivo | 5α-Androst-16-en-3α-ol formula | 5α-Androst-16-en-3α-ol molecular weight