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5-A-RU

Name: 5-A-RU
Brand: TargetMol
SKU: T10165
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T10165Cas No. 17014-74-3

Alias 5-Amino-6-(D-ribitylamino)uracil

5-A-RU (5-Amino-6-(D-ribitylamino)uracil) is an early intermediate in riboflavin biosynthesis and is found in a variety of bacteria and yeast as well as plants. 5-A-RU is also a mucosal-associated invariant T (MAIT) cell activator that forms potent MAIT-activating antigens through non-enzymatic reactions with small molecules from other metabolic pathways.

5-A-RU

Catalog No. T10165Alias 5-Amino-6-(D-ribitylamino)uracilCas No. 17014-74-3

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5 mg	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	5-A-RU (5-Amino-6-(D-ribitylamino)uracil) is an early intermediate in riboflavin biosynthesis and is found in a variety of bacteria and yeast as well as plants. 5-A-RU is also a mucosal-associated invariant T (MAIT) cell activator that forms potent MAIT-activating antigens through non-enzymatic reactions with small molecules from other metabolic pathways.
In vitro	METHODS: 5-A-RU plus DHA, 5-A-RU, 5-A-RU plus MeG, or 5-A-RU (0-3000μM) was used to treat mouse MAIT cells from STg (iVα19) and DTg (iVα19Vβ6) animals, and the activation of mouse MAIT cells was measured. RESULTS 5-A-RU plus MeG achieved the greatest MAIT cell activation; 5-A-RU alone also activated MAIT cells; 5-A-RU can also react with Glyx and MeG to produce pyrimidine adducts, activating mouse MAIT cells. [2]
In vivo	METHODS: 5-A-RU (100 nM, intraperitoneal injection) was administered to Vβ6-Tg mice and iVα19-Tg mice, and MAIT cell activation was measured. RESULTS MAIT cells were activated when 5-A-RU and MeG were mixed extemporaneously before in vivo injection, whereas 5-A-RU alone was unable to activate MAIT cells in mice. [2]
Alias	5-Amino-6-(D-ribitylamino)uracil

Chemical Properties

Molecular Weight	276.249
Formula	C₉H₁₆N₄O₆
Cas No.	17014-74-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

5-A-RU5 A RU5ARU