Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

5-Chlorouracil

😃Good
Catalog No. T36235Cas No. 1820-81-1

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil .

5-Chlorouracil

5-Chlorouracil

😃Good
Catalog No. T36235Cas No. 1820-81-1
5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil .
Pack SizePriceAvailabilityQuantity
5 g$93 35 days
10 g$163 35 days
25 g$290 35 days
50 g$533 35 days
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.3,4References
5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.3,4
References
In vivo
In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic. Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed. 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.
Chemical Properties
Molecular Weight146.53
FormulaC4H3ClN2O2
Cas No.1820-81-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
PBS (pH 7.2): 60 mg/mL (409.47 mM), Sonication is recommended.
DMF: 8 mg/mL (54.6 mM), Sonication is recommended.
DMSO: 0.8 mg/mL (5.46 mM), Sonication is recommended.
Ethanol: 53 mg/mL (361.7 mM), Sonication is recommended.
Solution Preparation Table
DMSO/DMF/Ethanol/PBS (pH 7.2)
1mg5mg10mg50mg
1 mM6.8245 mL34.1227 mL68.2454 mL341.2271 mL
5 mM1.3649 mL6.8245 mL13.6491 mL68.2454 mL
DMF/Ethanol/PBS (pH 7.2)
1mg5mg10mg50mg
10 mM0.6825 mL3.4123 mL6.8245 mL34.1227 mL
20 mM0.3412 mL1.7061 mL3.4123 mL17.0614 mL
50 mM0.1365 mL0.6825 mL1.3649 mL6.8245 mL
Ethanol/PBS (pH 7.2)
1mg5mg10mg50mg
100 mM0.0682 mL0.3412 mL0.6825 mL3.4123 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy 5-Chlorouracil | purchase 5-Chlorouracil | 5-Chlorouracil cost | order 5-Chlorouracil | 5-Chlorouracil chemical structure | 5-Chlorouracil in vivo | 5-Chlorouracil formula | 5-Chlorouracil molecular weight