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5-Fluorouridine 5'-O-β-D-galactopyranoside

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Catalog No. T38987Cas No. 149965-92-4
Alias 5'-O-β-D-galactosyl-5-fluorouridine, 5-Fluorouridine 5'-O-β-D-galactopyranoside

5-Fluorouridine 5'-O-β-D-galactopyranoside (also known as 5'-O-β-D-galactosyl-5-fluorouridine) is a prodrug of 5-Fluorouridine. It can be enzymatically converted by β-D-galactosidase into 5-Fluorouridine, a highly effective antineoplastic agent.

5-Fluorouridine 5'-O-β-D-galactopyranoside

5-Fluorouridine 5'-O-β-D-galactopyranoside

😃Good
Catalog No. T38987Alias 5'-O-β-D-galactosyl-5-fluorouridine, 5-Fluorouridine 5'-O-β-D-galactopyranosideCas No. 149965-92-4
5-Fluorouridine 5'-O-β-D-galactopyranoside (also known as 5'-O-β-D-galactosyl-5-fluorouridine) is a prodrug of 5-Fluorouridine. It can be enzymatically converted by β-D-galactosidase into 5-Fluorouridine, a highly effective antineoplastic agent.
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Product Introduction

Bioactivity
Description
5-Fluorouridine 5'-O-β-D-galactopyranoside (also known as 5'-O-β-D-galactosyl-5-fluorouridine) is a prodrug of 5-Fluorouridine. It can be enzymatically converted by β-D-galactosidase into 5-Fluorouridine, a highly effective antineoplastic agent.
In vitro
The IC50 ratio of 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) to 5-Fluorouridine, evaluated across various in vitro tumor cell lines, varied between 500:1 to 1000:1[1].
In vivo
5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) demonstrates over 100 times less toxicity to bone marrow cells in Balb/c mice compared to 5-Fluorouridine.
Alias5'-O-β-D-galactosyl-5-fluorouridine, 5-Fluorouridine 5'-O-β-D-galactopyranoside
Chemical Properties
Molecular Weight424.334
FormulaC15H21FN2O11
Cas No.149965-92-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

5-Fluorouridine 5'-O-b-D-galactopyranoside5'-O-b-D-galactosyl-5-fluorouridine5-Fluorouridine 5'-O-beta-D-galactopyranoside5'-O-beta-D-galactosyl-5-fluorouridine5Fluorouridine 5'OβDgalactopyranoside5 Fluorouridine 5' O β D galactopyranoside
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