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5-hydroxy Indomethacin

Name: 5-hydroxy Indomethacin
Brand: TargetMol
SKU: T37210
Rating: 4.5 (1 reviews)

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Catalog No. T37210Cas No. 2504-32-7

5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes.

5-hydroxy Indomethacin

😃Good

Catalog No. T37210Cas No. 2504-32-7

5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes.

Pack Size	Price	Availability
5 mg	Inquiry	35 days
10 mg	Inquiry	35 days
25 mg	Inquiry	35 days

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Resource Download

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Product Introduction

Bioactivity

Description

5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes.
1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fetal rabbit hepatocytesPediatr. Res.15(11)1406-1410(1981)

Chemical Properties

Molecular Weight	343.76
Formula	C₁₈H₁₄ClNO₄
Cas No.	2504-32-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMF: 30 mg/mL (87.27 mM), Sonication is recommended.

DMSO: 15 mg/mL (43.64 mM), Sonication is recommended.

Ethanol: 3 mg/mL (8.73 mM), Sonication is recommended.

PBS (pH 7.2): Insouble

Solution Preparation Table

Ethanol/DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	2.9090 mL	14.5450 mL	29.0901 mL	145.4503 mL
5 mM	0.5818 mL	2.9090 mL	5.8180 mL	29.0901 mL

DMSO/DMF

	1mg	5mg	10mg	50mg
10 mM	0.2909 mL	1.4545 mL	2.9090 mL	14.5450 mL
20 mM	0.1455 mL	0.7273 mL	1.4545 mL	7.2725 mL

DMF

	1mg	5mg	10mg	50mg
50 mM	0.0582 mL	0.2909 mL	0.5818 mL	2.9090 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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