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5-hydroxy Propranolol

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Catalog No. T36237Cas No. 81907-82-6

5-hydroxy Propranolol is a metabolite of propranolol , a β-adrenergic receptor antagonist. Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generation of 5-hydroxy propranolol and related metabolites.

5-hydroxy Propranolol

5-hydroxy Propranolol

😃Good
Catalog No. T36237Cas No. 81907-82-6
5-hydroxy Propranolol is a metabolite of propranolol , a β-adrenergic receptor antagonist. Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generation of 5-hydroxy propranolol and related metabolites.
Pack SizePriceAvailabilityQuantity
500 μg$233 35 days
1 mg$365 35 days
5 mg$1,710 35 days
10 mg$2,960 35 days
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Product Introduction

Bioactivity
Description
5-hydroxy Propranolol is a metabolite of propranolol , a β-adrenergic receptor antagonist. Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generation of 5-hydroxy propranolol and related metabolites.
Chemical Properties
Molecular Weight275.348
FormulaC16H21NO3
Cas No.81907-82-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 30 mg/mL (108.95 mM), Sonication is recommended.
DMSO: 30 mg/mL (108.95 mM), Sonication is recommended.
DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL (1.82 mM), Sonication is recommended.
DMF: 50 mg/mL (181.59 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM0.7264 mL3.6318 mL7.2635 mL36.3177 mL
10 mM0.3632 mL1.8159 mL3.6318 mL18.1588 mL
20 mM0.1816 mL0.9079 mL1.8159 mL9.0794 mL
50 mM0.0726 mL0.3632 mL0.7264 mL3.6318 mL
100 mM0.0363 mL0.1816 mL0.3632 mL1.8159 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

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